Click on the tab to search across Lilly for additional information

The Healthcare Professional's connection to Lilly product and condition information

Search across Lilly Select a search category, select a topic from the pull-down menu, add optional keyword(s), then click on the search button

Product:

Condition:

Byetta^®
(exenatide) injection Capastat^® Sulfate
(capreomycin for injection, USP) Cialis^®
(tadalafil) Cymbalta^®
(duloxetine hydrochloride) Evista^®
(raloxifene HCl) Forteo^®
(teriparatide [rDNA origin] injection) Lilly Glucagon
(glucagon by injection [rDNA origin]) Humalog^®
(insulin lispro injection [rDNA origin]) Humalog^® Mix50/50™
(50% insulin lispro protamine suspension, 50% insulin lispro injection [rDNA origin]) Humalog^® Mix75/25™
(75% insulin lispro protamine suspension, 25% insulin lispro injection [rDNA origin]) Humulin^®
(human insulin [rDNA origin]) Humatrope^®
(somatropin [rDNA origin] for injection) Prozac^®
(fluoxetine hydrochloride) Quinidine Gluconate Injection, USP
ReoPro^®
(abciximab) Seromycin^®
(cycloserine capsules, USP) Symbyax^®
(olanzapine and fluoxetine hydrochloride) Xigris^®
(drotrecogin alfa [activated]) Zyprexa^®
(olanzapine)

Acute Bipolar Mania Adult Growth Hormone Deficiency Bipolar Depression Diabetes Diabetic Peripheral Neuropathic Pain (DPNP) Erectile Dysfunction Idiopathic Short Stature (ISS) Major Depressive Disorder (MDD) Osteoporosis Pediatric Growth Hormone Deficiency Schizophrenia Severe Sepsis Turner Syndrome

Click on the tab to search across Lilly for additional information

Cymbalta® (duloxetine HCl) is approved for the treatment of depression and generalized anxiety disorder, and for the management of diabetic peripheral neuropathic pain and fibromyalgia.

Product Information

Mechanism of Action

Although the exact mechanisms of the antidepressant, anxiolytic, and analgesic actions of Cymbalta in humans are unknown, these actions are believed to be related to its potentiation of serotonergic and noradrenergic activity in the central nervous system (CNS).¹

Alterations in serotonin and norepinephrine in the brain are believed to be associated with major depressive disorder (MDD) and generalized anxiety disorder (GAD).^2,3 In the CNS, serotonin and norepinephrine are believed to act via descending pain pathways to reduce the perception of pain by dampening pain signals ascending to the brain from the dorsal horn.⁴

Serotonin and Norepinephrine Reuptake Inhibition

References:

Cymbalta full Prescribing Information, 2009.
Bymaster FL, et al. Neuropsychopharmacology. 2001;25(6):871-880.
Gorman IM, et al. Psychopharmacol Bull. 2002; 36(suppl 2):49-67.
Woolf CJ. Anasthesiology. 2007; 106:864-867.

Formulary Access Finder

Cymbalta has been added to the Anthem Blue Cross Blue Shield National Preferred Formulary.

Get more information about the formulary access for Cymbalta. Download PDF files of insurance providers covering Cymbalta in your state.

Register to Receive Information From Cymbalta

Keep up-to-date on the latest developments with Cymbalta. Sign up now for our periodic emails.